You'll no longer be able to override Gatekeeper in macOS Sequoia with a keyboard shortcut as Apple continues to crack down on unsigned software.
If you try to install apps on macOS that haven't been signed or notarized, Gatekeeper gets in the way and won't let it run. Apple has removed an age-old shortcut for skipping the Gatekeeper prompt in macOS Sequoia.
Until macOS Sequoia, users could hold Control and click on a freshly installed app to avoid Gatekeeper's warnings about running unsafe software. Now, users must navigate to System Settings then Privacy & Security to allow the app to run.